Omega-3 fatty acids can play a role in preventing cardiovascular disease, but vitamin D supplements cannot

0
92

br>

Source / information

Published by:

Source:

Manson JE. Nanette Wenger, MD, award and teaching assignment. Presented at: American Society for Preventive Cardiology Congress on CVD Prevention; 23-25 July 2021 (virtual meeting).

Disclosure:
Manson does not report any relevant financial information. For the VITAL study, BASF and Pharmavite provided study active ingredients free of charge, and Quest Diagnostics provided measurements and biomarker tests free of charge.

ADD SUBJECT TO EMAIL ALERTS

Receive an email when new articles are published on

Please enter your email address to receive an email when new articles are published on . “data-action =” subscribe “> subscribe

We could not process your request. Please try again later. If this problem persists, please contact customerservice@slackinc.com.

Back to Healio

Studies of omega-3 fatty acids have shown that they could play a role in preventing cardiovascular disease, but that doesn’t apply to vitamin D supplements, according to a spokesman.

In the VITAL study, marine omega-3s did not significantly reduce serious adverse cardiovascular events, mainly because they did not affect stroke, but they did reduce the risk of heart attack compared to placebo. JoAnn E. Manson, MD, DrPH, FAHA, Head of Preventive Medicine Department at Brigham and Women’s Hospital and Professor of Medicine and Michael and Lee Bell Professor of Women’s Health at Harvard Medical School said during the Nanette Wenger, MD, Award Lecture at the American Society for Preventive Cardiology’s virtual convention on CVD -Prevention.

Woman taking omega-3 pills from bottle.

Source: Adobe Stock

In the REDUCE-IT study, pharmaceutical-grade omega-3 fatty acid icosapentethyl (Vascepa, Amarin) reduced the risk of serious adverse cardiovascular events, as well as cardiovascular death, MI and stroke individually, Manson said, noting that meta-analyzes showed that omega-3 fatty acids appear to reduce the risk of CHD and CVD at higher doses and possibly higher concentrations of eicosapentaenoic acid and lower / no concentrations of docosahexaenoic acid.

However, she said that VITAL and other studies found no evidence of preventing CVD with vitamin D supplementation, although there may be evidence of preventing cancer mortality.

The implications for primary CVD prevention include encouraging fish consumption of at least two servings per week, Manson said.

JoAnn E. Manson

“Even if marine omega-3s have no cardiovascular benefits, the fish will replace less healthy foods like red meat or processed foods,” she said. “For those who consume little fish, either because they really don’t like fish or simply don’t eat fish, if they are not allergic they should speak to their doctor about taking a marine omega-3 supplement. Those who are vegetarian or vegan may want to speak to their doctor about an algae-based dietary supplement. “

A replication study of omega-3 fatty acids in high-risk patients, especially blacks who need primary prevention, should be conducted, she said.

For vitamin D supplementation, “the results would not suggest a clear change to the 2011 National Academy of Medicine guidelines that said there is no clear evidence that vitamin D reduces cardiovascular disease,” she said. “We need additional research on cancer, especially the benefits of cancer death. Doctors have plenty of leeway to give higher doses of vitamin D to patients with osteoporosis, bone health disorders, absorption disorders, or inflammatory bowel / celiac disease. We recommend avoiding megadoses of 10,000 IU and higher as their safety has not been proven with long-term use. “

More long-term use and additional results of VITAL are expected to be published over the next 6 months, and the VIVID randomized study of vitamin D 3,200 IU per day for the prevention of severe symptoms in patients with COVID-19 is underway, Manson said .

References:

ADD SUBJECT TO EMAIL ALERTS

Receive an email when new articles are published on

Please enter your email address to receive an email when new articles are published on . “data-action =” subscribe “> subscribe

We could not process your request. Please try again later. If this problem persists, please contact customerservice@slackinc.com.

Back to Healio

American Society for Preventive Cardiology

American Society for Preventive Cardiology

LEAVE A REPLY

Please enter your comment!
Please enter your name here