Ingesting fish oil can reduce antibiotic resistance

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Dr. Bart Eijkelkamp (left) and researchers Felice Adams and Maoge Zang from the Institute for Bacterial Host Adaptation at Flinders University, South Australia.Credits: Flinders University

For the first time, Australian scientists have identified the association of normal fish oil with the role of “super-bugs” in destroying the ability of “super-bugs” to resist antibiotics.

Discoveries just published in an international journal led by Flinders University, mBioDiscovered the Antibacterial Power of Fish Oil Fatty Acid A Simple and Safe Diet Supplement That People Can Consume Antibiotics To Make The Fight Against Infectious Diseases More Effective.

“Our study shows that key intracellular antibiotic resistance mechanisms can be compromised by the ingestion of omega-3 fatty acids in food,” said Flinders University Bacteria. Dr. Bart Eijkelkamp, ​​a microbiologist who runs the Host Adaptation Laboratory, said.

“Experimental and complementary supercomputer models have shown that these fatty acids in fish oil make bacteria more sensitive to a large number of common antibiotics.”

“This void in the harmful bacterial armor is an important step in the fight against the growing number of super bugs that are emerging. Multidrug Resistance For Antibiotics, ”said co-author Megan Omara, Associate Professor at the Australian National University.

This study is essential in the area of ​​infections caused by bacteria such as Acinetobacter baumannii, the leading pathogen of nosocomial infections with unprecedented antibiotic resistance worldwide.

“With the advent of the superbug, greedy bacteria can no longer distinguish between” good “hosts and bad host fatty acids and can show that they consume all of them during infection,” another co-author. said Dr. Felise Adams. Flinders University.

“Our study showed that fish oil fatty acids become part of the bacterial membrane and cause invasion. Bacteria The membrane is highly permeable and sensitive to the antibiotics with which it is attacked. “

“Acinetobacter baumannii is known as one of the most notorious multi-drug resistant pathogens in the world, but how it reacts to host-mediated stress is not well understood.”

“These studies provide new insights into the potential benefits of omega-3 supplements. Bacterial infection “Especially during antibiotic treatment,” said Professor Anton Peleg, director of the Infectious Diseases Department at Alfred Hospital in Melbourne.

Scientists are studying phages capable of producing the world’s leading superbug, Acinetobacter baumannii. kill

For more informations:
First article, To Make or Take: To make or take: Infected Bacterial Lipid Homeostasis (2021): Felise G Adams, Claudia Trappetti, Jack K Waters, Maoge Zang, Erin B Brazel, James C Paton, Marten F Snel Edited by Bart A Eijkelkamp mBio DOI: 10.1128 / mBio.00928-21

Detailed analysis, membrane composition, spatial composition and function of the most important active substance excretion system of Acinetobacter baumannii (2021) by Maoge Zang, Hugo MacDermott-Opeskin, Felise G. Adams, Varsha Naidu, Jack K. Waters, Ashley B. Carey, Alex Ashenden Define. , Kimberly T. McLean, Erin B. Brazel, The Han Jean, Alessandra Panitza, Claudia Trapetti, James C. Paton, Anton Y. Peleg, Ingo Caper, Ian T. Paulsen, Karl ・ Edited by A. Hassan, Megan L. Omara and Bad Ekelkamp mBio DOI: 10.1128 / mBio.01070-21

Journal information:
mBio

Provided by
Flinders University

Quote: New protection against super bugs: Fish oil can reduce antibiotic resistance (June 9, 2021) https://phys.org/news/2021-06-defense-superbugs-fish-oil-antibiotic.html

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