Correlative analysis of vitamin D and omega-3 fatty acid intake in men for active prostate cancer monitoring

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Urology. June 15, 2021: S0090-4295 (21) 00525-2. doi: 10.1016 / j.urology.2021.04.050. Online before printing.

ABSTRACT

OBJECTIVES: To study the influence of targeted serum vitamin D levels and the omega-6: 3 fatty acid ratio on prostate specific antigen (PSA) levels in men with prostate cancer who are actively monitored by a Nutritional intervention and vitamin supplementation were addressed.

METHODS: 68 patients with very low or low risk NCCN biopsy-screened prostate cancer were admitted to the Cleveland Clinic’s Prostate Cancer Nutrition and Genetics Clinic from July 2013 to December 2019, animal products and foods containing omega-6 polyunsaturated fatty acids (PUFAs) contain. The supplementary regimen consisted of: Omega-3 PUFAs 720 mg (three / day); Curcumin 2000 mg / day; Vitamin D3 dose titrated to achieve a serum level of 60 ng / ml; and vitamin B complex 1000 mg (four times a week). Patients were given regular monitoring of PSA, serum vitamin D, and PUFA levels, and were frequently assessed by a dietitian who included a frequency of food intake questionnaire. An interval biopsy of the prostate was performed as clinically indicated and / or after nine months.

RESULTS: The mean and 95% confidence intervals (CI) of the increase in PSA and the increase in serum vitamin D levels were 0.11 (0-0.25) ng / ml / month and 4.65 (3, 09-5.98) ng / ml / month. Patients with higher initial vitamin D levels were twice as likely to have a downward trend in PSA (OR = 2.04, 95% CI 1.04-4.01, p = 0.04). Follow-up biopsy was performed in 55 patients, all of whom showed no disease progression. Three patients had loose stools that required an adjustment of the omega-3 and / or curcumin dose.

CONCLUSIONS: Intensive nutritional intervention with vitamin D and omega-3 PUFA supplementation may benefit men under active surveillance for prostate cancer, and further study is warranted.

PMID: 34144071 | DOI: 10.1016 / j.urology.2021.04.050

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